Hexapeptide-11 Powder

Xi'an Le-Nutra Ingredients Inc is one of the most professional manufacturers and suppliers of hexapeptide-11 powder in China, featured by quality products and low price. Please rest assured to wholesale bulk hexapeptide-11 powder for sale here from our factory. Customized orders are welcome.

Hexapeptide-11 is a synthetic peptide with the amino acid sequence Phe-Val-Ala-Pro-Phe-Pro (FVAPFP). It was originally isolated from yeast extracts and later produced through solid-phase synthesis to high purity . The peptide belongs to the cosmetic anti-aging category, with a molecular weight of 676.81 Da and CAS number 161258-30-6.

What makes this peptide distinct from common cosmetic peptides is its mechanism. Hexapeptide-11 modulates the proteostasis network-the cellular system that manages protein folding, degradation, and recycling. Research on human fibroblasts shows it activates proteasome, autophagy, chaperone, and antioxidant response genes in a dose- and time-dependent manner . It also promotes nuclear accumulation of Nrf2, a key regulator of antioxidant defenses.

Our Hexapeptide-11 Powder is a white to off-white lyophilized powder with high HPLC purity. It dissolves in water and suits serum, cream, and gel formulations. The recommended use level in cosmetic products is quite low, with research partners reporting improvements in dermal texture at concentrations as low as 0.01%.

We supply Hexapeptide-11 Powder with a focus on sequence identity and batch consistency. The peptide is a six-amino-acid chain, and synthesis byproducts can affect purity and performance. Our material is tested by HPLC to confirm ≥98% purity, with identity confirmed by mass spectrometry.

Every batch ships with a Certificate of Analysis covering purity, water content, acetate content, and mass spec identity. We report the actual values. The powder is packaged and stored under conditions that protect it from moisture and degradation.

I have seen peptide powders that pass a generic purity spec but fail sequence confirmation. For a cosmetic peptide with a specific mechanism, identity is not optional-it is the difference between the intended active and a related impurity. Our COA includes the mass spec result. When a customer tells me their serum performed as expected in stability testing, that is the confirmation that the material was right.

Proteostasis Network Modulation
Hexapeptide-11 Powder activates proteasome, autophagy, chaperone, and antioxidant response pathways in human fibroblasts. It promotes Nrf2 nuclear accumulation and increases proteasome peptidase activities, supporting the cell's natural protein quality-control systems.

Anti-Aging and Skin Elasticity
In vivo skin deformation assays in human subjects showed improved skin elasticity after Hexapeptide-11 Powder treatment . Research also indicates it reversibly downregulates ATM and p53 expression, influencing the onset of cellular senescence in aged fibroblasts.

Antioxidant Protection
The peptide inhibits oxidative damage in fibroblasts and upregulates antioxidant genes. This supports positioning for products targeting environmental stress and premature aging.

Collagen and ECM Support
Research shows Hexapeptide-11 stimulates fibroblast activity through pathways including TGF-β, promoting collagen I/III and elastin synthesis. This contributes to skin firmness and structural integrity.

Formulation Compatibility
The peptide dissolves readily in water at room temperature, making it suitable for aqueous serums, emulsions, and gels. It is compatible with common cosmetic ingredients including hyaluronic acid and vitamin C.

Anti-Aging Serums
Hexapeptide-11 Powder suits concentrated serums targeting firmness, elasticity, and cellular senescence. The low use level makes it practical for premium formulations.

Eye Creams and Targeted Treatments
The peptide can be incorporated into eye creams and spot treatments addressing fine lines and texture. Its mechanism supports structural skin improvement over time.

Moisturizers and Day Creams
Daily moisturizers benefit from the peptide's antioxidant and proteostasis support. It can be combined with hyaluronic acid for hydration and vitamin C for complementary antioxidant activity.

Hair Serums
Research indicates Hexapeptide-11 Powder may influence hair follicle cells. Some formulators use it in hair serums targeting scalp and follicle health.

Sheet Masks and Hydrogels
The water solubility and low use level make it suitable for sheet mask essences and hydrogel patches for intensive anti-aging treatments.

Q: What is the recommended use level for Hexapeptide-11 Powder?
A: Research partners report improvements in dermal texture at concentrations as low as 0.01%. Cosmetic suppliers typically recommend 0.01% to 1.0% depending on the formulation and target claims. Contact us for specific guidance.

Q: How should I store the powder?
A: Store at 2–8°C, protected from light and moisture. The lyophilized powder is stable under these conditions for 24 months.

Q: What is the mechanism of action?
A: Hexapeptide-11 Powder modulates the proteostasis network, activating proteasome, autophagy, and antioxidant responses. It also supports Nrf2 nuclear accumulation and influences cellular senescence pathways.

Q: Can it be combined with vitamin C?
A: Yes. The mechanisms are complementary. Hexapeptide-11 focuses on proteostasis and cellular repair, while vitamin C provides antioxidant and collagen-support benefits.

Q: Is this product suitable for sensitive skin?
A: The peptide is designed for cosmetic use and shows a favorable safety profile in research. As with any active, formulators should follow appropriate use levels and conduct compatibility testing.

Q: Can you provide samples?
A: Yes. We send small quantities with a Certificate of Analysis for qualified customers. Contact us with your requirements.

To explore how our Hydrolysed Rice Peptide can enhance your products, contact us at info@lenutra.com, aimee@lenutra.com