Acetyl Hexapeptide-38 Powder

Xi'an Le-Nutra Ingredients Inc is one of the most professional manufacturers and suppliers of acetyl hexapeptide-38 powder in China, featured by quality products and low price. Please rest assured to wholesale bulk acetyl hexapeptide-38 powder for sale here from our factory. Customized orders are welcome.

Acetyl Hexapeptide-38 is a synthetic acetylated hexapeptide with the sequence Ac-Ser-Val-Val-Val-Arg-Thr-NH2. It is also known by the trade name Adifyline . Unlike most cosmetic peptides that target wrinkles through muscle relaxation or collagen stimulation, this peptide works through a different pathway: it promotes adipogenesis, the formation of new fat cells in the subcutaneous layer.

The mechanism centers on PGC-1α, a transcriptional coactivator that interacts with PPARγ to modulate adipogenesis rate . In vitro studies on preadipocyte cultures showed that 0.5 mg/mL of Acetyl Hexapeptide-38 induced a 61.1% increase in PGC-1α expression and a 32.4% increase in lipid accumulation after 10 days.

Our Acetyl Hexapeptide-38 Powder is a white to off-white powder with high HPLC purity. It dissolves freely in water and polyols, making it suitable for serums, creams, and eye contour products. The recommended active peptide level in finished formulations is 0.005% to 0.05% (50–500 ppm).

What I find practical about this peptide is the positioning. Aging doesn't just cause wrinkles-it causes volume loss. Cheeks flatten, temples hollow, and the under-eye area looks gaunt. This peptide addresses that specific concern by supporting the fat layer beneath the skin. For formulators building contour or plumping products, it offers a mechanism that complements collagen-focused peptides rather than duplicating them.

We supply Acetyl Hexapeptide-38 Powder with a focus on sequence identity and batch consistency. The peptide is a six-amino-acid chain with a specific acetylation modification. That acetylation is not decorative-it makes the molecule less prone to premature oxidation and helps it survive formulation conditions . Our material is tested by HPLC to confirm ≥98% purity, with identity confirmed by mass spectrometry.

Every batch ships with a Certificate of Analysis covering purity, water content, acetate content, and mass spec identity. We report the actual values, not just pass/fail results. The powder is packaged under nitrogen and stored under conditions that protect it from moisture and degradation.

I have seen peptide powders that pass a generic purity spec but show inconsistent solubility or activity from batch to batch. For a cosmetic peptide used at low percentages, that inconsistency can throw off a formulation. Our material dissolves clear and performs predictably. When a customer tells me their contour serum or eye cream held its texture and stability through testing, that is the confirmation that the starting material was solid.

Adipogenesis and Volume Support
Acetyl Hexapeptide-38 Powder upregulates PGC-1α expression, which drives preadipocyte differentiation and lipid accumulation in subcutaneous tissue . This mechanism supports facial volume in areas that thin with age, such as cheeks and temples.

Contour and Plumping Effect
By promoting local fat tissue volume, the peptide helps improve the appearance of gauntness and soft tissue loss. It is used in formulations targeting facial contour, cheek volume, and lip plumping.

Skin Barrier and Irritation Mitigation
Research shows Acetyl Hexapeptide-38 Powder decreases IL-8 secretion in human keratinocytes, suggesting a role in mitigating skin irritation and supporting barrier function . This makes it suitable for products targeting sensitive or compromised skin.

Synergy with Other Actives
The peptide is compatible with hyaluronic acid, vitamin complexes, and botanical actives. Formulators can build multi-pathway anti-aging systems that address both collagen support and volume restoration.

• Facial Contour Serums and Creams

Acetyl Hexapeptide-38 Powder suits serums, ampoules, and creams targeting cheek volume, facial contour, and mid-face fullness. The recommended stock solution addition is 2% for a 0.05% active peptide level.

• Eye Contour Products

The peptide works in eye creams and serums addressing under-eye hollowing and gaunt appearance. It can be combined with hyaluronic acid for hydration and peptides for collagen support.

• Lip Plumping Products

Formulations targeting visually fuller lips can incorporate the peptide. It supports volume in the lip area without the irritation associated with some plumping agents.

• Neck and Jawline Care

Products targeting sagging or loss of definition along the jawline can use Acetyl Hexapeptide-38 for its volume-supporting mechanism.

Q: What is the recommended use level for Acetyl Hexapeptide-38 Powder?
A: The recommended active peptide level in finished formulations is 0.005% to 0.05% (50–500 ppm) . For a 1000 ppm stock solution, typical addition is 1–3% for serums and creams, 2–3% for lip products, and 1–2% for eye creams.

Q: How should I store the powder?
A: Store at 2–8°C short-term, or -20°C for long-term storage, protected from light and moisture . The powder is stable under these conditions for 24 months.

Q: What is the mechanism of action?
A: The peptide upregulates PGC-1α expression, which promotes preadipocyte differentiation and lipid accumulation in subcutaneous tissue. This supports facial volume in areas that thin with age.

Q: Is this the same as Acetyl Hexapeptide-8 (Argireline)?
A: No. Acetyl Hexapeptide-8 targets muscle signaling pathways for dynamic wrinkles. Acetyl Hexapeptide-38 regulates lipid metabolism in subcutaneous preadipocytes for contour plumping. Their sequences and targets are completely different.

Q: Can it be combined with other anti-aging peptides?
A: Yes. The peptide is compatible with hyaluronic acid and other actives. It complements collagen-stimulating peptides because it addresses volume loss rather than collagen synthesis alone.

Q: Can you provide samples?
A: Yes. We send small quantities with a Certificate of Analysis for qualified customers. Contact us with your requirements.

To explore how our Hydrolysed Rice Peptide can enhance your products, contact us at info@lenutra.com, aimee@lenutra.com