Pentapeptide-18 Powder

Xi'an Le-Nutra Ingredients Inc is one of the most professional manufacturers and suppliers of pentapeptide-18 powder in China, featured by quality products and low price. Please rest assured to wholesale bulk pentapeptide-18 powder for sale here from our factory. Customized orders are welcome.

Pentapeptide-18 is a synthetic five-amino-acid peptide with the sequence H-Tyr-D-Ala-Gly-Phe-Leu-OH. It is also known by the trade name Leuphasyl . The peptide belongs to the neuropeptide family and was developed as a topical alternative for targeting expression lines.

The mechanism is inspired by enkephalins, the body's natural calming neuropeptides. Pentapeptide-18 binds to enkephalin receptors on nerve cells and partially reduces acetylcholine release. Less acetylcholine means the small facial muscles contract less intensely, which softens the appearance of dynamic wrinkles over time.

Our Pentapeptide-18 Powder is a white to off-white lyophilized powder with high HPLC purity. It dissolves in water and suits serum, cream, and eye contour formulations. The recommended use level in finished cosmetics is 0.005% to 0.05% on a pure peptide basis, though clinical testing has evaluated concentrations up to 2%.

What I find practical about this peptide is the clinical threshold. A study testing three formulations at 0.5%, 1%, and 2% found that only the 2% concentration produced significant wrinkle improvement . That is a useful data point for formulators. It tells you the peptide works, but the dose needs to be high enough to matter. Undert dosing is a common mistake with neuropeptides.

We supply Pentapeptide-18 Powder with a focus on sequence identity and batch consistency. The peptide is a five-amino-acid chain, and synthesis byproducts can affect both purity and performance. Our material is tested by HPLC to confirm ≥98% purity, with identity confirmed by mass spectrometry.

Every batch ships with a Certificate of Analysis covering purity, water content, acetate content, and mass spec identity. We report the actual values, not just pass/fail results. The powder is packaged and stored under conditions that protect it from moisture and degradation.

I have seen peptide powders that pass a generic purity spec but fail sequence confirmation. For a cosmetic peptide with a specific mechanism, identity is not optional. It is the difference between the intended active and a related impurity. Our COA includes the mass spec result. When a customer tells me their serum performed as expected in stability testing, that is the confirmation that the material was right.

• Expression Line Softening

Pentapeptide-18 Powder modulates neuromuscular communication by mimicking enkephalins. It binds to receptors on nerve endings and reduces acetylcholine release, which decreases the intensity of repeated micro-contractions that form expression lines . Clinical evaluation at 2% concentration showed a 34.7% reduction in frown lines and 28.4% reduction in eye contour wrinkles.

• Synergistic Combination with Argireline

In vivo studies have confirmed that pentapeptide-18 combined with acetyl hexapeptide-3 (Argireline) produces a synergistic anti-wrinkle effect that is superior to either peptide alone . The two peptides act at different points in the same neurotransmitter release pathway.

• Broad Anti-Aging Potential

Recent computational and spectroscopic research suggests pentapeptide-18 interacts with skin-aging-related signaling proteins including TGF-β receptor-I, TNF-α, and MAPK14 pathways. This indicates the peptide's effects may extend beyond neuromodulation to influence cellular aging processes.

• Formulation Stability

The peptide is stable at pH 4.0 to 7.0, which covers the typical range for facial serums and creams. Formulators should avoid combining it with strongly acidic preparations such as high-concentration AHA/BHA products.

Anti-Aging Serums and Creams
Pentapeptide-18 Powder suits concentrated serums and creams targeting forehead lines, crow's feet, and other expression wrinkles. The clinical data at 2% supports this positioning.

Eye Contour Products
The peptide is well-suited for eye creams and gels. The clinical study reported a 28.4% reduction in eye contour wrinkles at 2% concentration.

Synergistic Peptide Blends
Formulators can combine pentapeptide-18 with acetyl hexapeptide-8 (Argireline) for enhanced anti-wrinkle effects, as in vivo data shows synergy between the two.

Lip Care
Repeated micro-contractions around the mouth contribute to lip lines. The peptide can be incorporated into lip serums and balms targeting this area.

Q: What is the recommended use level for Pentapeptide-18 Powder?
A: The recommended level in finished cosmetics is 0.005% to 0.05% on a pure peptide basis . However, clinical testing found that only a 2% concentration produced significant wrinkle improvement . Formulators should balance efficacy data with cost and sensory considerations.

Q: How should I store the powder?
A: Store at 2–8°C, protected from light and moisture. The lyophilized powder is stable under these conditions for 24 months.

Q: What is the mechanism of action?
A: Pentapeptide-18 Powder mimics enkephalins, binding to receptors on nerve cells and reducing acetylcholine release. This decreases the intensity of facial muscle micro-contractions that form expression lines.

Q: Can it be combined with Argireline?
A: Yes. In vivo studies show a synergistic anti-wrinkle effect when pentapeptide-18 is combined with acetyl hexapeptide-3 (Argireline).

Q: Is this product suitable for sensitive skin?
A: Pentapeptide-18 is generally reported as well tolerated, with low irritation potential at cosmetic use levels. As with any active, a patch test is reasonable for sensitive skin.

Q: Can you provide samples?
A: Yes. We send small quantities with a Certificate of Analysis for qualified customers. Contact us with your requirements.

To explore how our Hydrolysed Rice Peptide can enhance your products, contact us at info@lenutra.com, aimee@lenutra.com